Polynucleotide Treatment

At London Lip Clinic on Harley Street, we provide personalised polynucleotide treatments designed to support skin hydration, texture, elasticity and overall quality. Treatment can be tailored to different areas, including the face, neck, décolletage, hands and delicate skin around the eyes.

Every appointment begins with a consultation and skin assessment with Rupesh Shah.

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What our customers are saying

      EXCELLENT  
   Based on 132 reviews 
    
 
 
 
   
 
 
       Posted on Google  
   
   Nicole M. Mathieu 
 17. October, 2025.
 
 
 Trustindex verifies that the original source of the review is Google. DR. Rupesh was outstanding I’m so so happy with the results. Put me at ease and very helpful and the procedure was quick, pain free and easy ☺️
  
 
      Posted on Google  
   
   Maria Trupiano 
 16. September, 2025.
 
 
 Trustindex verifies that the original source of the review is Google. I’ve been seeing Rupesh for my Botox for over 6 years now and it’s always a pleasure. Results are always amazing and Rupesh is just a wonderful person to be around - even if for 15 mins at a time. Could not recommend more!
  
 
      Posted on Google  
   
   Ugo Chira 
 15. September, 2025.
 
 
 Trustindex verifies that the original source of the review is Google. Rupesh was an amazing practitioner. From when I arrived, he explained the full procedure to me making sure to highlight the after-care and what I need to do for the best results. He talked me through everything he was doing and made me feel at ease. The Botox procedure was seamless and was very quick. I told him my problem areas and he made sure to explain how this is going to help that. He was very knowledgeable and even recommended other services based on my future needs giving me the pros and cons for each one. I left very happy and I will definitely be back when I need a top up, and recommend him to everyone. Thanks a lot, Rupesh!
  
 
      Posted on Google  
   
   Sarah Domingues 
 14. September, 2025.
 
 
 Trustindex verifies that the original source of the review is Google. I had an amazing experience with Dr. Rupesh at the London Lip Clinic. I had been struggling with excessive underarm sweating for a long time—it was really uncomfortable and started affecting my confidence. I tried different roll-ons recommended by my GP, but nothing worked.

A friend of mine mentioned that her sister had the same issue and got treated by Dr. Rupesh with Botox for hyperhidrosis, and it worked really well for her. That gave me the push I needed to book a consultation.

Honestly, I wasn’t sure if the treatment would work for me, and I was also a bit scared about the pain and the whole process. But Dr. Rupesh was incredibly patient, kind, and professional. He took the time to explain everything in detail and really helped put my mind at ease.

He mentioned that results can start showing anywhere from 5 days to 3 weeks, depending on the person. For me, I noticed a difference the very next day! It’s now been 3 weeks since my treatment, and I haven’t experienced any sweating at all—I’m honestly so happy with the results.

I highly recommend Dr. Rupesh and the team at London Lip Clinic. Thank you so much for looking after me!
  
 
      Posted on Google  
   
   K DL 
 11. September, 2025.
 
 
 Trustindex verifies that the original source of the review is Google. This was my second visit to Rupesh the treatment of profhilo . What a brilliant treatment I see results on my first visit 4 weeks apart, I went back yesterday had my 2nd lot . I must say I can’t wait to see my results it gets better in time .My face looks fresher more supple skin , this is truly a good treatment . Highly recommend  . It didn’t hurt just like having Botox, not to much down time which is good.
I must say Rupesh is a genius , he’s brilliant at what he does, nice mannered genuine .
Thank you 🙏
I be back for my lips soon
  
 
      Posted on Google  
   
   s bog 
 15. August, 2025.
 
 
 Trustindex verifies that the original source of the review is Google. Rupesh is an amazing man and practitioner. He takes such good and skilled technical care with treatment and is generous in tweaking results later and so achieves the best result of any such doctor I have had anywhere in the world. But it is the human being who so readily comes through that makes him especially good at his craft and with his patients. I have been seeing Rupesh for well over two years now and have gotten to know him as a person. He is dedicated to his parents, to his family and thoughtful about life, how to raise children, how others feel and how he can help them. An authentic and skilled man. Thank you Rupesh - this review was long-planned but well overdue.
  
 
      Posted on Google  
   
   Colette Blair 
 14. August, 2025.
 
 
 Trustindex verifies that the original source of the review is Google. Rupesh makes you feel relaxed and comfortable and is excellent at his job, ensuring you get exactly the level of improvement you desire. His honesty and professionalism ensure there is no hard sell which is unusual (and greatly appreciated) in this field. His aftercare is reassuring and informative. I wouldn’t go anywhere else again and have no doubts recommending him and his clinic.
  
 
      Posted on Google  
   
   arvydas sbs 
 10. August, 2025.
 
 
 Trustindex verifies that the original source of the review is Google. satisfied with the procedure performed, thank you

What Is Polynucleotide Treatment?

Polynucleotide treatment is an injectable skin treatment that uses purified nucleotide-based compounds to support the condition and appearance of the skin. The product is placed into selected areas through a series of small injections, with the treatment pattern adapted to your skin and concerns.

A polynucleotide skin treatment may help support hydration, elasticity and the appearance of fine lines or uneven texture. Changes generally develop gradually as the skin responds to treatment, although results and their duration vary between individuals.

Unlike dermal fillers, polynucleotides are not primarily used to add facial volume or reshape individual features. They focus on skin quality and may be considered for delicate or visibly ageing areas where improving hydration and texture is the main objective.

At London Lip Clinic, Rupesh will assess your skin before recommending a suitable product, treatment area and number of sessions.

What Areas Polynucleotide Can Treat

Polynucleotide treatment can be adapted to several areas of the face and body. The appropriate product and injection technique will depend on the thickness and condition of the skin, the concern being addressed and your individual treatment plan.

Full Face

A polynucleotide facial treatment may be used to support hydration, texture, elasticity and overall skin quality across suitable areas of the face. It is intended to create gradual improvements without primarily adding volume or altering facial contours.

Under Eyes

A polynucleotide under eye treatment may help improve hydration and the appearance of fine or crepey skin around the eyes. It may also be considered for some types of dark circles, although suitability will depend on their underlying cause.

Dark circles can be influenced by pigmentation, visible blood vessels, skin quality, facial anatomy or volume loss. Rupesh will assess the area before advising whether polynucleotides are appropriate.

Crow's Feet

Polynucleotides may be used to support skin quality and improve the appearance of fine lines around the outer eye area. The treatment focuses on the condition of the skin rather than relaxing the muscles responsible for facial expression.

Forehead

Treatment across the forehead may support hydration, texture and the appearance of fine lines. Rupesh will assess the skin and movement of the area before recommending an appropriate approach.

Cheeks

Polynucleotide treatment may help support hydration, elasticity and skin quality across the cheeks. It does not primarily add the volume or structural definition associated with dermal fillers.

Perioral Area

The skin around the mouth may develop fine lines, dehydration and changes in texture. Polynucleotides can be used to support skin quality in this area without primarily adding volume to the lips or surrounding tissues.

Neck

Treatment may support hydration and improve the appearance of crepey skin, uneven texture and fine horizontal lines across the neck. The likely response will depend on the degree of skin laxity and the concerns being addressed.

Décolletage

The décolletage is regularly exposed to sunlight and may develop visible changes in hydration, texture and elasticity. Polynucleotide treatment may be used to support skin quality and improve the appearance of fine lines across this area.

Persistent or changing areas of pigmentation should be medically assessed before cosmetic treatment is considered.

Hands

Polynucleotides may be used to support hydration and improve the appearance of texture and general skin quality across the backs of the hands.

Acne Scars

Polynucleotide treatment may form part of a wider treatment plan for selected types of mild acne scarring. The appropriate approach will depend on the type, depth and extent of the scars.

Stretch Marks

Polynucleotides may be considered for selected areas affected by stretch marks, with the aim of supporting skin quality and texture. Their suitability and likely effect will depend on the age, colour and depth of the stretch marks.

Post Laser and Post Procedure Skin

Polynucleotides may sometimes be incorporated into a wider plan following suitable aesthetic procedures. They may be considered alongside treatments such as microneedling, with the timing determined by the procedures involved and Rupesh’s assessment.

Procedure Time
30–45 minutes

No. of Treatments
3 treatments recommended, approximately 2–4 weeks apart

Results Last
6–12 months, with maintenance treatments recommended every 6–9 months depending on skin condition and lifestyle

Price
£300/Syringe

Why Choose London Lip Clinic

At London Lip Clinic, every polynucleotide treatment begins with an individual consultation and skin assessment. Rupesh will review your concerns, medical history, previous aesthetic procedures and goals before explaining whether treatment is suitable and what it may realistically achieve.

The focus is on improving skin quality through a measured and personalised approach. You will receive information about the proposed product, treatment areas, expected limitations, potential risks, aftercare and pricing before deciding whether to proceed.

Medically Led Harley Street Clinic

London Lip Clinic is located at 8 Harley Street in central London. Consultations and treatments are provided in a professional and discreet clinical setting, with patient care and informed decision-making central to the treatment process.

Treatments Performed by Rupesh Shah

Your consultation and polynucleotide treatment will be personally carried out by Rupesh Shah. This provides continuity from your initial assessment through to treatment, aftercare and any appropriate follow-up.

Over 23 Years of Clinical Experience

Rupesh has more than 23 years of clinical healthcare experience. His approach combines an understanding of facial anatomy, skin health, medicines and aesthetic treatment planning.

Advanced Regenerative Aesthetic Treatments

Polynucleotides may be used alone or incorporated into a wider skin treatment plan. Depending on your skin and goals, Rupesh may discuss complementary options such as microneedling, mesotherapy skin boosters or Profhilo treatment.

Where changes in facial volume or contour are the main concern, dermal fillers may be considered instead of or alongside skin-focused treatments.

Rupesh will explain how the available procedures differ and whether a combined approach is appropriate. Treatments may need to be separated by a suitable interval.

Personalised Skin Assessment and Treatment Plans

No two people have the same skin or treatment goals. Your consultation will include an assessment of your skin quality, facial anatomy, medical history and the areas you would like to address.

This information will be used to recommend a suitable product, treatment area, number of syringes and proposed course.

Natural Looking, Long Lasting Results

Polynucleotide treatment is intended to support gradual changes in skin quality rather than dramatically alter your appearance. The aim is to improve hydration, texture and elasticity while maintaining your individual features.

Results develop differently for every patient and cannot be guaranteed. Their duration will depend on the product used, treatment course, skin condition, lifestyle and individual response.

Premium Polynucleotide Products

London Lip Clinic uses carefully selected polynucleotide products from established manufacturers. The product recommended for you will depend on your skin, the area being treated and the intended purpose of treatment.

Rupesh will explain which product is proposed and why it has been selected during your consultation.

GPhC Registered Healthcare Professional

Rupesh is registered with the General Pharmaceutical Council. His healthcare background informs the consultation, medical history review, product selection and safety considerations involved in your treatment.

Committed to Patient Safety

Every treatment begins with a consultation to determine whether the procedure is appropriate. London Lip Clinic follows infection control, assessment and aftercare procedures designed to reduce avoidable risks and support informed treatment decisions.

Potential side effects and limitations will be explained before treatment. No injectable procedure is entirely without risk.

Comprehensive Before and Aftercare

You will receive guidance on preparing for your appointment and caring for the treated area afterwards. The clinic will explain which temporary reactions may occur and when you should seek further advice.

Transparent Pricing

The amount of product required and the total treatment cost will be discussed during your consultation. You will have the opportunity to ask questions and understand the proposed plan before proceeding.

At London Lip Clinic, our philosophy is simple: restore healthier skin from within using evidence-based regenerative treatments that deliver subtle, natural and long-lasting results. Our goal is to help you look refreshed, rejuvenated and confident—never overdone.

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Make the Most of Your Appointment

MAKING THE MOST OF YOUR APPOINTMENT AT LONDON LIP CLINIC

Preparing appropriately for your appointment can help reduce the risk of bruising, irritation and other temporary reactions.

Before your treatment:

Attend your consultation with Rupesh to discuss your skin, medical history and goals
Avoid alcohol for 24 hours before your appointment
Tell the clinic about any medication or supplements you take
Do not stop prescribed medication unless advised by the healthcare professional responsible for your care
Arrive with clean skin that is free from make-up where possible
Stay well hydrated
Inform the clinic if you have an active cold sore, skin infection, rash or feel unwell
Tell Rupesh if you are pregnant or breastfeeding, as treatment may need to be postponed
Mention any recent or planned aesthetic procedures

Your appointment will begin with a skin assessment and confirmation of the agreed treatment plan. The treatment area will then be cleansed, and a topical numbing cream may be applied where appropriate.

Small amounts of the selected polynucleotide product will be placed into the targeted areas using fine needles or a cannula. The technique used will depend on the product, area and treatment plan. Discomfort varies between individuals, but measures can be taken to help make the procedure more comfortable.

The appointment typically takes around 30 to 45 minutes.

Following treatment, you may experience redness, swelling, tenderness, bruising or small raised areas at the injection points. These effects commonly settle within several days, although recovery varies.

After your treatment:

Avoid touching, rubbing or massaging the area unless advised otherwise
Avoid make-up for 12 to 24 hours
Avoid strenuous exercise for 24 to 48 hours
Avoid saunas, steam rooms and hot baths for 24 to 48 hours
Avoid alcohol for 24 hours
Limit excessive sun exposure
Use a broad-spectrum SPF 30 or higher
Keep your skin hydrated with suitable skincare products
Follow any personalised instructions provided by the clinic

Contact London Lip Clinic if you experience increasing pain, significant swelling, skin discolouration or any unexpected symptoms.

Polynucleotide Treatment Prices in London

Polynucleotide Treatment

Under-Eye Polynucleotide Treatment

Advanced regenerative treatment to improve dark circles, fine lines, crepey skin and overall skin quality around the delicate eye area.

1 Syringe £300

Face Polynucleotide Treatment

Full facial skin rejuvenation to stimulate collagen, improve hydration, elasticity and overall skin quality.

1 Syringe £300

Neck Polynucleotide Treatment

Improve skin firmness, texture and crepiness while restoring a smoother, more youthful-looking neck.

1 Syringe £300

Décolletage Polynucleotide Treatment

Rejuvenate the chest area by improving fine lines, sun damage and skin texture.

1 Syringe £300

Hands Polynucleotide Treatment

Restore hydration and improve skin quality for smoother, healthier-looking hands.

1 Syringe £300

1 Syringe Polynucleotide

£300

2 Syringes Polynucleotide

£550

3 Syringes Polynucleotide

£750

Book Your Polynucleotide Treatment Consultation

Take the first step towards healthier, firmer and more radiant skin with a free private Polynucleotide Treatment consultation at London Lip Clinic, Harley Street. During your consultation, Rupesh Shah will assess your skin, discuss your concerns and create a personalised treatment plan tailored to your aesthetic goals.

Whether you’re looking to rejuvenate the face, improve the delicate under-eye area or restore skin quality to the neck or décolletage, we’re here to help you achieve natural-looking, long-lasting results.

8 Harley Street, London, W1G 9QY

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Polynucleotide Treatment FAQs

How many polynucleotide treatments will I need?

Most patients achieve the best results with a course of three treatments, usually spaced two to four weeks apart. The exact number will depend on your skin condition, treatment goals and how your skin responds. During your consultation, we’ll create a personalised treatment plan tailored to you.

How long does it take to see results from polynucleotides?

Unlike dermal fillers, polynucleotides work by stimulating your body’s natural regeneration processes. Many patients begin noticing improvements after a few weeks, with optimal results typically developing over two to three months as collagen production increases.

Are polynucleotides better than Profhilo?

Both treatments improve skin quality, but work in different ways. Polynucleotides focus on tissue repair and collagen stimulation, making them ideal for improving skin texture and elasticity, as well as delicate areas such as the under-eye area.

Profhilo primarily delivers intense hydration while also stimulating collagen and elastin. During your consultation, we’ll recommend the most suitable option for your concerns or discuss whether a combination approach may be beneficial.

Can polynucleotides be combined with other skin treatments?

Yes. Polynucleotides are often combined with other regenerative treatments to achieve more comprehensive skin rejuvenation. Depending on your goals, your practitioner may recommend combining them with mesotherapy skin boosters, Profhilo or other aesthetic treatments as part of a personalised treatment plan.

Are polynucleotide injections painful?

Most patients find the treatment very tolerable. The injections are performed using very fine needles, and a topical numbing cream can be applied beforehand to improve comfort. You may experience mild stinging or slight discomfort, but the procedure is generally well-tolerated.

Who is a good candidate for polynucleotide treatment?

Polynucleotides are suitable for adults looking to improve skin quality, reduce fine lines, treat sun-damaged skin, improve skin elasticity or rejuvenate delicate areas such as the under-eye region. A consultation is essential to determine whether the treatment is appropriate for your individual needs and medical history.

How long do the results of polynucleotide treatment last?

Results vary between patients, but improvements typically last around 6–12 months. Many patients choose periodic maintenance treatments to help preserve their results and continue supporting healthy collagen production.

What should I avoid after polynucleotide treatment?

For the first 24 to 48 hours, it’s recommended that you avoid strenuous exercise, saunas, steam rooms, alcohol, excessive sun exposure and applying make-up to the treated area. Following your aftercare advice will help support healing and optimise your results.

What are some of the best polynucleotide injections?

The “best” polynucleotide injections can vary depending on individual skin concerns, desired outcomes, and practitioner preference. Here are some of the most popular and well-regarded polynucleotide injection brands in the market:

Nucleofill
Plinest
Rejuran

Is there any downtime after polynucleotide treatment?

Downtime is minimal. You may experience slight redness, swelling or small bumps at the injection sites immediately after treatment, which usually settle within 24 to 48 hours. Mild bruising can occasionally occur, particularly around delicate areas such as the eyes.

What Rejuran Products Do You Offer?

Rejuran Healer

Rejuran Healer may be considered as part of a polynucleotide facial treatment for concerns relating to skin texture, hydration, elasticity, fine lines and overall skin quality.

It may be suitable for:

Fine lines
Uneven texture
Changes in elasticity
Dehydrated or dull skin
Selected types of acne scarring
General facial skin rejuvenation

Rejuran I

Rejuran I is designed for use around the delicate eye area. It may be considered for a polynucleotide under eye treatment following an assessment of the skin and the underlying cause of the concern.

It may be suitable for:

Fine lines
Crepey under eye skin
Dehydration
Changes in under eye skin quality
Selected types of dark circles

Rejuran S

Rejuran S is a more concentrated formulation that may be considered for selected areas affected by textural irregularities or acne scarring.

It may be suitable for:

Selected acne scars
Uneven skin texture
Localised areas requiring a more targeted approach

The appropriate Rejuran product and treatment plan will be determined during your consultation with Rupesh.