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What is Polynucleotide Treatment ?

Polynucleotide Treatment is an advanced regenerative injectable treatment that repairs, rejuvenates and revitalises the skin from within. Derived from highly purified DNA fragments, polynucleotides stimulate your body’s natural production of collagen and elastin, improve skin hydration, reduce inflammation and support tissue repair, resulting in healthier, firmer and more radiant skin.

Unlike traditional dermal fillers, polynucleotides do not add volume or alter facial contours. Instead, they improve skin quality by enhancing elasticity, reducing fine lines, improving texture and strengthening the skin’s natural barrier. They are particularly effective for treating the face, neck, décolletage and delicate under-eye area.

Polynucleotide Treatment Areas

Polynucleotide Treatment is a versatile regenerative injectable that can improve skin quality across multiple areas of the face and body. By stimulating collagen production, improving hydration and encouraging tissue repair, it helps restore healthier, firmer and more youthful-looking skin without adding volume.

Full Face

Improve skin texture, hydration, elasticity and overall radiance.

Under Eyes

Reduce crepey skin, improve dark circles caused by thin skin, and refresh tired-looking eyes.

Crow's Feet

Soften fine lines around the eyes and improve skin quality.

Forehead

Enhance skin texture and reduce fine lines.

Cheeks

Improve firmness, elasticity and collagen production.

Perioral Area

Smooth fine lines around the mouth and improve skin quality.

Neck

Improve skin laxity, crepiness and horizontal neck lines.

Décolletage

Rejuvenate sun-damaged skin and reduce fine lines across the chest.

Hands

Restore hydration and improve the appearance of ageing skin.

Acne Scars

Support skin regeneration and improve the appearance of mild atrophic acne scars.

Stretch Marks

Improve skin quality and texture in selected areas.

Post-Laser & Post-Procedure Skin

Promote tissue repair and support recovery following suitable aesthetic treatments.

London Lip Clinic

At a glance

Procedure Time
30mins

No. of Treatments
3 treatments recommended, approximately 2–4 weeks apart

Results Last
6–12 months, with maintenance treatments recommended every 6–9 months depending on skin condition and lifestyle

Price
£300/Syringe

Why Choose London Lip Clinic for Your Lip Flip Treatment?

WHY CHOOSE LONDON LIP CLINIC FOR YOUR Polynucleotide Treatment?

At London Lip Clinic, we combine medical expertise with the latest regenerative aesthetic treatments to help you achieve healthier, firmer and more radiant skin. Polynucleotide Treatment is a cutting-edge injectable treatment that stimulates your body’s natural repair processes, improving collagen production, skin elasticity and hydration for natural-looking rejuvenation.

Your treatment is performed by Rupesh Shah, an experienced medically qualified aesthetic practitioner with over 23 years of clinical experience. Every treatment plan is tailored to your individual skin concerns, ensuring safe, effective and personalised results. Whether you’re looking to rejuvenate the face, improve the delicate under-eye area or restore skin quality to the neck or décolletage, we create bespoke treatment plans designed to enhance your natural beauty without changing your facial features.

Located at 8 Harley Street, London, London Lip Clinic provides advanced aesthetic treatments in one of the world’s most prestigious medical districts. Our medically led approach ensures every treatment is performed with patient safety, clinical excellence and natural-looking results at the forefront.

Every Polynucleotide Treatment is personally carried out by Rupesh Shah, ensuring continuity of care from your consultation through to treatment and follow-up. You will always be treated by an experienced medical professional, never delegated to another practitioner.

With more than two decades of healthcare experience, Rupesh combines extensive medical knowledge with advanced aesthetic expertise. His understanding of facial anatomy, skin health and regenerative medicine allows him to deliver safe, personalised and predictable results.

We offer the latest evidence-based regenerative treatments designed to stimulate your body’s natural healing processes. Polynucleotides improve skin quality by encouraging collagen and elastin production, enhancing hydration and supporting long-term skin rejuvenation without adding artificial volume.

No two patients are the same. Every consultation includes a detailed assessment of your skin quality, facial anatomy and aesthetic goals, allowing us to create a bespoke treatment plan tailored specifically to your needs and desired outcomes.

Our philosophy is to enhance your natural beauty rather than change your appearance. Polynucleotide Treatments gradually improve skin quality, elasticity and radiance, providing subtle, refreshed and youthful-looking results that continue to develop over time.

We use only carefully selected, high-quality Polynucleotide products from trusted manufacturers, chosen for their safety profile, purity and proven ability to stimulate skin regeneration and improve overall skin quality.

The delicate under-eye area requires precision and experience. We have extensive expertise in treating dark circles associated with thin skin, crepey skin, fine lines and tired-looking eyes using regenerative techniques that improve skin quality while maintaining a natural appearance.

Polynucleotide Treatment is highly versatile and can rejuvenate multiple areas of the body. Whether treating the face, neck, chest or hands, every treatment is carefully tailored to improve skin texture, firmness, hydration and elasticity.

London Lip Clinic is proud to be Save Face Registered, demonstrating our commitment to the highest standards of patient safety, clinical governance and ethical practice. Patients can feel confident knowing they are choosing a clinic independently assessed for quality and safety.

As a General Pharmaceutical Council (GPhC) Registered Pharmacist, Rupesh practises within strict professional and ethical standards. Patients benefit from a strong medical background, comprehensive knowledge of medicines and a safety-first approach to every treatment.

Patient wellbeing is our highest priority. We follow rigorous infection control procedures, comprehensive consultation protocols and evidence-based treatment techniques to ensure every procedure is performed safely and professionally.

Exceptional patient care extends beyond your treatment. We provide detailed pre-treatment advice, personalised aftercare instructions and ongoing support to help optimise your results and ensure a smooth recovery.

We believe in honest, straightforward pricing with no hidden costs. Every treatment is discussed in detail during your consultation, ensuring you fully understand your personalised treatment plan and investment before proceeding.

London Lip Clinic welcomes patients of all genders, ethnicities and backgrounds. We provide a discreet, friendly and professional environment where every patient receives personalised care, respect and treatment tailored to their individual aesthetic goals.

At London Lip Clinic, our philosophy is simple: restore healthier skin from within using evidence-based regenerative treatments that deliver subtle, natural and long-lasting results. Our goal is to help you look refreshed, rejuvenated and confident—never overdone.

Book a Consultation

MAKING THE MOST OF YOUR POLYNUCLEOTIDE TREATMENT

MAKING THE MOST OF YOUR APPOINTMENT AT LONDON LIP CLINIC

Preparing your skin properly can help maximise the benefits of your Polynucleotide Treatment and minimise the risk of bruising or swelling.

  • Attend your consultation with Rupesh Shah to discuss your medical history, skin concerns and treatment goals.
  • Avoid alcohol for 24 hours before your appointment.
  • Where medically appropriate, avoid blood-thinning medications and supplements (such as aspirin, ibuprofen, fish oils, vitamin E and ginkgo biloba) for 3–7 days before treatment. Never stop prescribed medication without first consulting your GP or prescribing clinician.
  • Arrive with clean skin, free from make-up, moisturiser and sunscreen if possible.
  • Stay well hydrated before your appointment.
  • Inform your practitioner if you have an active cold sore, skin infection, rash or are feeling unwell, as treatment may need to be postponed.
  • If you are pregnant or breastfeeding, Polynucleotide Treatment is not recommended.

Your comfort and safety are our priority throughout your appointment at London Lip Clinic.

  • Your treatment begins with a comprehensive skin assessment and personalised treatment plan.
  • The treatment area is thoroughly cleansed and disinfected.
  • A topical anaesthetic cream may be applied where appropriate to improve comfort.
  • Small amounts of Polynucleotide product are carefully injected into the targeted areas using fine needles or a cannula, depending on the treatment area.
  • Most patients describe the treatment as very well tolerated, with only mild discomfort.
  • The procedure typically takes 30–45 minutes.
  • Mild redness, small bumps or slight swelling at the injection sites are normal and usually settle within 24–48 hours.

Following the correct aftercare will help optimise your results and support your skin’s natural regenerative process.

  • Avoid touching, rubbing or massaging the treated areas for at least 6 hours unless advised otherwise.
  • Avoid make-up for 12–24 hours.
  • Avoid strenuous exercise, saunas, steam rooms and hot baths for 24–48 hours.
  • Avoid alcohol for 24 hours after treatment.
  • Protect your skin from excessive sun exposure and wear a broad-spectrum SPF 30 or higher every day.
  • Keep your skin well hydrated using a gentle moisturiser recommended by your practitioner.
  • Mild swelling, redness, tenderness or bruising can occur and usually resolves within a few days.
  • Contact London Lip Clinic immediately if you experience increasing pain, significant swelling, skin discolouration or any unexpected symptoms.

Polynucleotide Treatment Prices in London

Under-Eye Polynucleotide Treatment

Advanced regenerative treatment to improve dark circles, fine lines, crepey skin and overall skin quality around the delicate eye area.

1 Syringe £300

Face Polynucleotide Treatment

Full facial skin rejuvenation to stimulate collagen, improve hydration, elasticity and overall skin quality.

1 Syringe £300

Neck Polynucleotide Treatment

Improve skin firmness, texture and crepiness while restoring a smoother, more youthful-looking neck.

1 Syringe £300

Décolletage Polynucleotide Treatment

Rejuvenate the chest area by improving fine lines, sun damage and skin texture.

1 Syringe £300

Hands Polynucleotide Treatment

Restore hydration and improve skin quality for smoother, healthier-looking hands.

1 Syringe £300

1 Syringe Polynucleotide

£300

2 Syringes Polynucleotide

£550

3 Syringes Polynucleotide

£750

London Lip Clinic

Book now for your free private Polynucleotide Treatment consultation in LONDON

Take the first step towards healthier, firmer and more radiant skin with a free private Polynucleotide Treatment consultation at London Lip Clinic, Harley Street. During your consultation, Rupesh Shah will assess your skin, discuss your concerns and create a personalised treatment plan tailored to your aesthetic goals.

Whether you’re looking to rejuvenate the face, improve the delicate under-eye area or restore skin quality to the neck or décolletage, we’re here to help you achieve natural-looking, long-lasting results.

8 Harley Street, London, W1G 9QY

BOOK A CONSULTATION

Most patients achieve the best results with a course of three treatments, usually spaced two to four weeks apart. The exact number will depend on your skin condition, treatment goals and how your skin responds. During your consultation, we’ll create a personalised treatment plan tailored to you.

Unlike dermal fillers, polynucleotides work by stimulating your body’s natural regeneration processes. Many patients begin noticing improvements after a few weeks, with optimal results typically developing over two to three months as collagen production increases.

Both treatments improve skin quality, but work in different ways. Polynucleotides focus on tissue repair and collagen stimulation, making them ideal for improving skin texture and elasticity, as well as delicate areas such as the under-eye area.

Profhilo primarily delivers intense hydration while also stimulating collagen and elastin. During your consultation, we’ll recommend the most suitable option for your concerns or discuss whether a combination approach may be beneficial.

Yes. Polynucleotides are often combined with other regenerative treatments to achieve more comprehensive skin rejuvenation. Depending on your goals, your practitioner may recommend combining them with mesotherapy skin boosters, Profhilo or other aesthetic treatments as part of a personalised treatment plan.

Most patients find the treatment very tolerable. The injections are performed using very fine needles, and a topical numbing cream can be applied beforehand to improve comfort. You may experience mild stinging or slight discomfort, but the procedure is generally well-tolerated.

Polynucleotides are suitable for adults looking to improve skin quality, reduce fine lines, treat sun-damaged skin, improve skin elasticity or rejuvenate delicate areas such as the under-eye region. A consultation is essential to determine whether the treatment is appropriate for your individual needs and medical history.

Results vary between patients, but improvements typically last around six to nine months. Many patients choose periodic maintenance treatments to help preserve their results and continue supporting healthy collagen production.

For the first 24 to 48 hours, it’s recommended that you avoid strenuous exercise, saunas, steam rooms, alcohol, excessive sun exposure and applying make-up to the treated area. Following your aftercare advice will help support healing and optimise your results.

The “best” polynucleotide injections can vary depending on individual skin concerns, desired outcomes, and practitioner preference. Here are some of the most popular and well-regarded polynucleotide injection brands in the market:

  • Nucleofill
  • Plinest
  • Reguran

Downtime is minimal. You may experience slight redness, swelling or small bumps at the injection sites immediately after treatment, which usually settle within 24 to 48 hours. Mild bruising can occasionally occur, particularly around delicate areas such as the eyes.

Welcome to the London Lip Clinic, situated at our premier clinical practice on world-renowned Harley Street. We offer cutting-edge regenerative injectable solutions designed to structurally restore your skin from the inside out.

Our advanced polynucleotide injection treatments utilise highly purified DNA fragments to accelerate deep tissue healing, stimulate localised collagen growth, and significantly refine overall skin texture. If you are searching for a non-surgical approach to achieve visibly smoother, plumper, and profoundly healthy skin, our bespoke clinical pathways deliver long-lasting, natural rejuvenation.

What Exactly Are Polynucleotides?

Polynucleotides for skin are biotechnologically derived compounds used in dermatology and cosmetic medicine to improve skin health and appearance. These polynucleotides are typically extracted from natural sources, such as salmon DNA, and are used in various treatments aimed at skin rejuvenation, repair, and hydration.

How Do Polynucleotides Work?

Polynucleotides work by providing the skin with nucleotides and nucleosides, the building blocks of DNA and RNA. These molecules are involved in various cellular processes, including:

  • Cellular Repair: By supplying nucleotides, polynucleotides support the repair of damaged DNA and RNA, which is crucial for maintaining healthy skin cells.
  • Stimulation of Growth Factors: Polynucleotides can stimulate the production of growth factors that enhance cell proliferation and tissue regeneration.
  • Enhanced Collagen Production: They boost the activity of fibroblasts, leading to increased collagen production, which is essential for maintaining skin structure and firmness.

What Are the Benefits of Polynucleotide Treatments?

  1. Skin Repair and Regeneration: Polynucleotides promote the repair and regeneration of skin cells by stimulating the production of fibroblasts, which are essential for collagen synthesis. This leads to improved skin texture and elasticity.
  2. Anti-Aging Effects: They help reduce the appearance of fine lines and wrinkles by enhancing the skin’s natural regenerative processes and increasing moisture retention.
  3. Hydration: Polynucleotides improve the skin’s ability to retain moisture, leading to better hydration and a plumper, more youthful appearance.
  4. Anti-Inflammatory Properties: These compounds have anti-inflammatory effects, which can help reduce redness, irritation, and other signs of inflammation.
  5. Wound Healing: Polynucleotides can accelerate wound healing by promoting cell proliferation and tissue repair.

What to Expect During a Polynucleotide Treatment:

During a polynucleotide treatment for skin rejuvenation, the procedure typically involves a series of steps designed to deliver these beneficial compounds effectively into the skin. Here’s what you can expect:

1. Consultation

  • Initial Assessment: A consultation with Rupesh to assess your skin condition, discuss your goals, and determine if polynucleotide treatment is suitable for you.
  • Medical History: Review of your medical history and any potential contraindications or allergies.

2. Preparation

  • Cleansing: The treatment area will be thoroughly cleansed to remove any makeup, oils, and impurities.
  • Topical Anaesthetic: A topical numbing cream may be applied to minimise discomfort during the procedure. This is typically left on for 20-30 minutes.

3. Injection Procedure of Polynucleotide treatment

  • Injection Technique: Polynucleotides line Nucleofill are usually administered through a series of microinjections using fine needles. The depth and distribution of the injections depend on the specific treatment protocol and the areas being targeted (e.g., face, neck, hands).
  • Target Areas: Common areas include fine lines, wrinkles, and areas needing volume or hydration improvement.
  • Duration: The injection process can take 30-60 minutes, depending on the size of the treatment area.

4. Post-Treatment Care of Polynucleotide treatment

  • Cooling and Soothing: Post-injection, the treated area may be cooled with ice packs or soothing gels to reduce any swelling or redness.
  • Instructions: You will receive aftercare instructions, which may include avoiding sun exposure, strenuous exercise, and certain skincare products for a few days.

5. Recovery and Results of Polynucleotide treatment

  • Immediate Effects: Some immediate improvement in skin hydration and plumpness might be noticeable, but the full effects will develop over time as the skin regenerates.
  • Downtime: Minimal downtime is typical, but you might experience mild redness, swelling, or bruising at the injection sites, which usually subsides within a few days.
  • Follow-Up: Multiple sessions may be recommended for optimal results, spaced a few weeks apart. The exact number of sessions will depend on your skin’s response and the specific goals of the treatment.

6. Expected Outcomes of Polynucleotide treatment

  • Improved Skin Texture: Smoother and more even skin texture.
  • Enhanced Elasticity and Firmness: Increased skin firmness and elasticity due to collagen stimulation.
  • Hydration and Radiance: Better skin hydration leading to a more radiant appearance.
  • Reduced Fine Lines and Wrinkles: A noticeable reduction in the appearance of fine lines and wrinkles over time.

Considerations

  • Qualified Practitioner: Ensure that the treatment is performed by a qualified & Experienced practitioner like Rupesh to minimise risks and maximise results.
  • Consistency: For best results, adhere to the recommended treatment schedule and follow all aftercare instructions provided by your practitioner.

In summary, polynucleotide treatments are minimally invasive procedures aimed at rejuvenating and revitalising the skin. The process involves preparation, injection, and post-treatment care, with results improving over a series of sessions.

Safety and Efficacy of Polynucleotide Treatment:

Polynucleotide treatments are generally considered safe and well-tolerated, with a low risk of adverse effects. They are biocompatible and do not provoke significant immune reactions. The efficacy of these treatments can vary depending on the individual and the specific formulation used.

 

Rejuran® polynucleotide treatment in London at London Lip Clinic is a regenerative injectable treatment designed to improve skin texture, reduce the appearance of acne scars and support under-eye rejuvenation for smoother, healthier-looking skin.

Performed at our Harley Street clinic by Rupesh Shah, an Independent Prescriber, Rejuran uses polynucleotides, also known as PDRN, to support collagen stimulation, tissue repair, hydration and long-term skin regeneration.

Rejuran® Products We Offer

Rejuran Healer (Face Rejuvenation)

Best for:

  • Skin ageing
  • Fine lines
  • Acne scars
  • Overall skin quality

✔ Improves skin texture and glow

✔ Boosts collagen and elastin

✔ Ideal as a full-face polynucleotide treatment

Rejuran I (Under Eye Polynucleotide)

Best for:

  • Dark circles
  • Crepey under eyes
  • Fine lines

✔ Specifically designed for delicate eye area

✔ Popular for polynucleotide under-eye treatment

✔ One of the most effective treatments for under-eye rejuvenation

Rejuran S (Acne Scars & Texture)

Best for:

  • Acne scars
  • Enlarged pores
  • Skin texture

✔ More concentrated formulation

✔ Targets scar remodelling and repair